Worlds first oral herbal Antivenom "PINAK".

DISCUSSION:

Though snakes are our friends, people are afraid of snake because of the deaths which can occur inspite of the availability of injection ASV. Incidence of snake bite is more in farmers. The time elapsed after the bite is important which determines whether damage is confined to local area or if systemic signs have developed. It is important to get a description of the snake involved as the snakes remain within 20 feet after biting. Identification of the snake guides the physician to know the type of snake so as to start appropriate treatment. It is also important know when was ligature tied and whether any treatment was given. Reduced muscular movements of the site of bite decrease the absorption of poison in systemic circulation; therefore immobilization is an important step.

Ligature was applied in 46 cases but if applied too tightly it obstructs arterial blood flow also and may cause ischaemic pain. Therefore ligature should be applied in such a way that only venous blood is obstructed and prevents systemic mixing of venom and hence it is a life saving first aid measure.

Incision was taken in only one case. It should be done with a clean blade1” long and 1: above and skin deep on both sides of the bite mark which helps in w\oozing out of the venom and hence dose of ASV required can be lessened.

Out of 75 cases 51 were brought to hospital after 2 hours of snake bite. It is advisable to bring the patient as early as possible to give ASV to avoid irreversible organ damage. Administration of local medicine like neem tree juice, etc. are responsible for delay which may cause severe vomiting leading to aspiration pneumonia.

After hospitalization, the physician must observe the patient meticulously for signs of toxicity. Usually neuroparalytic signs develop within one hour followed by vasculotoxicity. Plan of treatment is to start specific treatment only after signs of toxicity develop till complete neutralization of the poison. Treatment policies vary from hospital to hospital. Some may give one to two injections to all cases including nonpoisonous snake bites. Of course initation of ASV after signs of toxicity are seen need a confident, sincere and knowledgeable physician. The dose required is 5 vials for mild, 6-15 vials for moderate and 31-120 vials for very severe toxicity. Some physicians declare the patient ASV resistant if ASV requirement goes above 80 vials. While anti-venom is life saving, it may lead to immediate hypersensitivity (anaphylaxis) or delayed serum sickness, therefore must be used with caution.

A working SANJIVNI (Herb brought by Lord Hanuman for Laxman when he was bitten by a snake) named PINAK and KAPIS have been developed by us from traditional medicine for snakebite patients. These Ayurved medicines are being used for incurable or resistant cases or to treat cases living in inaccessible areas. We have used Tab PINAK August 2002 with successful results. It is a combination of four herbs. We have developed it as a sublingual tablet with sugar base as it is very bitter. Onset of action is within minutes and lasts for 6-12 hours. The dose required is 1-3 tablets for mild, 1-10 tablets for moderate and more than 10 tablets for severe toxicity. It is observed that BT and CT is controlled within 6 hours and swelling disappears completely at the earliest and reduces paralysis as well. Also we found that PINAK is a good and effective hemostatic agent. Along with this tablet KAPIS is given which is found to be good wound heeler. For faster results PINAK is given in powder form sublingually. The field care recommended is:

1. Immobilization of limb to prevent spread of venom.
2. Application of tourniquet one joint above the site of bite.  
3. Making a first aid and incision to remove venom.
4. Suction application at the site of bite by pump.
5. Do not give anything to eat or drink to prevent aspiration.
6. Remove anything that may constrict the limb.
7. Arrange transport to shift the patient to hospital.
8. Give ABC if required.

Thus tab PINAK as Ayruved medicine is an oral form of medicine which is cheaper, has no side effects, no expects, no expert or trained person is required for its administration. If given along with inj. ASV, requirement of ASV is reduced drastically.
As PINAK is a safe medicine if it is taken immediately after any snake bite, no person will die on road to a hospital.
Initially use of PINAK can be an adjuvant till a physician gets confidence of the drug.

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SUMMARY AND CONCLUSION:

In our pilot study of 28 patients of complicated snakebite, 15 patients received Pinak + ASV and control group 13 patients received only ASV.
Following observations were found:

1. No. of ASV vials requirement was less in Pinak group than control group. P < 0.05.
2. In neuroparalytic snakebite no significant difference was found in ASV requirement, but in vasculotoxic snakebite statistical significant difference was found in ASV requirement.
3. Complications are minimal, of less severity in Pinak group as compared to control group.
4. In neuroparalytic group recovery is fast in Pinak group and required less duration of ventilatory support as compared to control group.
5. No mortality, reaction to Pinak tablet was observed.
6. This is a Pilot study. Further detailed study with large no. of patients is required for definite recommendations.

Thus we conclude that Pinak tablet has supporting role in complicated snakebite but not substitute for ASV. Pinak has found to have reduced ASV requirement significantly.

USE OF “PINAK” IN THE TREATMENT OF SCROPION STINGS

Pinak is a an ayurvedic antivenin used for snake bite cases. Feedback from patients of scorpion stings stimulated us for this study. Now we have concluded that a single tablet of pinak is able to cure scorpion stings cases completely. More tablets may be required in few selected cases of scorpion stings. COMPOSITION: Erythrina indica, Magnefera indica, Eugenia jambolana, Jusminum sambac ACTION: Onset of action within few minutes, Duration of action in 6 to 12 hours. DOSAGE: MILD – 1-5 tabs., MODERATE – 5-10tabs., SEVERE –more than 10 tabs. ADVANTAGES : Oral, Sub lingual, Herbal, Safe No trained person required, can be taken everywhere. TOXICITY: This is absolutely safe medicine without any side effects. INDICATIONS: All Snake Bites, Scorpion stings, Bee’s bites.

fB psychology

facebook,twitter,linkedin,google plus and what not, man who claims himself to be a social being , is being exploited for this very nature, in the name of social networking....what are they actually ? why do we do so many things just to grab likes an comments on such platforms ? putting all sorts of posts ranging from content level zero to

hundred ! what a bull shit ! take a walk, play soccer, chess ! swim in the river (not the pool , i wouldnt advice that), have a fight or a quarrel with your friend or spouse, but use such sights judiciously ! fB is just a media, a media where our frequency of searches influence what we see, our stupidity is as such presented to the world, without any professionalism or editing, all sorts of rubbish talks, we are not concerned abt anything serious anymore, thats the point....but there are other things in life , world is not, life is not what u see in a fB post ! man is fB'ed ! just putting forward some of the psychological influences of fB,
-people present a positive self view to others when online, leading to an increase in self esteem and decrease in self control, so dont get upset if someone nearest to you most probably your mom complains you of being such a mess lately, it could be seen in your rooms order !
-users who did not personally know friends verywell believed others had better lives leading to lower self esteem, and ofcourse depression....you are hooked for entertainment or for information right, so next time go for some read (books, libraray) or watch some of your favourite films with your family or friends, not alone...again ! go out, discover your locality !
-intimate interactions lead to an elevated self esteem ! bah ...humbug ! what's d point ? huh ? self esteem, yeah its one of the ladders of needs towards reaching self actualisation , but a false one does not lead you there, you can be your king in your thoughts, i'd say it was better dreaming around late wake ups ! its said morning dreams do come true, so lets dream ! remember what dr.kalam said ? great people always had a dream to cherish ( "i have a dream"-martin luther king) that made their life a lesson for all human beings, that made great leaders, do you expect someone to lead you, its history, lead yourself !
-its an online equivalent of staring yourself at the mirror, nothing so important about your face or mind, its about how you percieve, not about how you see !
-fB is narcissism re-invented, damn i hate that word more than anything ! such people rot their lives, "this life is too short to live it just for you, but when you feel so powerless what are you gonna do ? so say what you want ....." havent you heard it ! (powerless by nellly furtado...go get some fine musical feasto !)
-fB induces a pervasive pattern of grandiosity, need for admiration and an exaggerated sense of self importance,
so long for those fB ying, venture out and make the most of your life ! im done fB ying !
Bye !